![]() ![]() ![]() PNCDI II: P4. "Partnerships in priority areas", D6. Biotechnology Financing contract no.: 61-002/2007 Project no.: 1885/2007 Obtaining and characterization of new targeted-nanodrugs with naphthoquinonic active substance |
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Summary NANOQMED is a multidisciplinary approach which includes the support brought by biotechnologies, coordinative chemistry, supramolecular chemistry and nanotechnologies for the development of new pharmaceutical products which can make up the basis of innovative therapies in human medicine (bio-active nanoproducts and nanomedicines, targeted-drugs with cellular specificity and reduced toxicity). Quinones are substances whose molecule contains a benzoquinone, naphtoquinone, anthraquinone or phentanthrene nucleus. It is well known that organic substances with the main structure of 1,4 naphtoquinone which have in positions 2,3 functional groups containing sulfur or nitrogen as donor atoms, can act as ligands to obtain coordinative compounds (complex combinations) with plain-square structure of cis-platin complexes (compounds with high anti-tumor action). In NANOQMED, we proposed chemosynthesis of new complex combinations of transitional metals with new ligands (naphthoquinones), having mercapto, hydroxyl, amide and amino groups. |
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Consortium The Consortium consists of six participating entities: five from the academic area and one from industry (SME).
Grant holder (Coordinator - CO): The National Research and Development Institute for Cryogenics and Isotopic Technologies – ICSI Rm. Valcea
------------------------------------------------------ Partner 1 (P1): National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca
------------------------------------------------------ Partner 2 (P2): University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca
------------------------------------------------------ Partner 3 (P3): Babeş-Bolyai University, Cluj-Napoca
------------------------------------------------------ Partner 4 (P4): Technical University of Cluj-Napoca
------------------------------------------------------ Partner 5 (P5): SC Imofarm Impex SRL, Bucharest
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Objectives The aim of NANOQMED is the obtaining of new encapsulated bio-active products and/or immonoconjugates with a high degree of specificity and reduced toxicity. In a specific manner, through planned activities for deployment, it will be followed the achievement of a series of specific objectives:
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Impact Evolution of NANOQMED will be made according with the strict deontological rules of scientific research, the project manager will take into account all the measurements required to insure the respecting of these rules. In this meaning, all members of the research team, who signed the project proposal, will be engaged to respect these rules. The team members will be engaged to notify the project manager, in any occasion which will generate a contradiction with the research deontological rules, in this way the required measurements will be taken.
Environmental impact
Social impact
Economical impact |
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Budget (in RON) |
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Project progress: dissemination, patents
Publications
B. Sevastre, I. Marcus, R. Tamaian, 2011, In silico identification of new antiproliferative compounds, inhibitors of matrix metalloproteinases. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 68(1):334-343.
R. Tamaian, V. Niculescu, M. Anghel, 2010, In silico predictions for improving permeability properties of principal anticancer anthracyclines through structural modification. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 67(1):329-336.
R. Tamaian, I. Marcus, V. Niculescu, B. Sevastre, M. Anghel, I. Prodan, 2010, Computational study of interspecies TOP2A similarities for further development of new double targeted therapeutic immunoconjugates. Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Veterinary Medicine, 67(1):373.
L.Szabó, V.Chiş, A.Pîrnău, N.Leopold, O.Cozar, Sz.Orosz, 2009, Spectroscopic and theoretical study of amlodipine besylate, Journal of Molecular Structure, 924–926:385-392, Show more, https://doi.org/10.1016/j.molstruc.2009.02.003.
V. Niculescu, R. Tamaian, N. Păun, A. Pîrnău, L. Szabó, 2009, Synthesis and spectral characterisation of a new metal complex with a bidentate ligand. Journal of Physics: Conference Series, 182(1):012030, doi:10.1088/1742-6596/182/1/012030.
R. Tamaian, B. Sevastre, V. Niculescu, I. Prodan, N. Păun, I. Marcus, 2009, Synthesis of New Kind of Naphthoquinonic Anti-Tumoural Compounds. Toxicity Tests. Romanian Journal of Biochemistry, 46(Suplementa):124-125.
R. Tamaian, N. Păun, V. Niculescu, A. Iordache, R. Vremeră, S. Broscătean, 2008, Antibiotic Effects of The Naphtoquinonic Derivative On Gram-Positive And Gram-Negative Germs. Chemické Listy, 102(15s):s479-481.
Manifestations:
The Second National Congress with International Participation of Integrative Medicines, 02 – 05 November 2011, Bucharest, Romania:
The 16th ICIT International Conference “Progress in Cryogenics and Isotopes Separation”, 13 – 15 October 2010, Călimăneşti-Căciulata, România:
Processes in Isotopes and Molecules – PIM 2009, 24-26 September 2009, Cluj-Napoca, Romania:
3rd International Conference on Advanced Spectroscopies on Biomedical and Nanostructured Systems – NANOSPEC 2008, 7-10 September 2008, Cluj-Napoca, Romania:
4th Central European Conference “Chemistry Towards Biology”, 08 – 11 September 2008 Dobogoko, Hungary:
Patents:
Patent RO 127496 – Immunoconjugates with antiproliferative naphthalendione cytotoxic payload (authors: Radu Tamaian, Ioan Marcus, Violeta-Carolina Niculescu, Bogdan Sevastre, Iulia Luciana Popescu) published in BOPI (The Official Industrial Property Bulletin of Romania), No. 8/2019, Section Patents, 30-08-2019, p. 75 (RO)
Patent RO 127619 – Naphthalendione derivate used in tumoral growth control (authors: Violeta-Carolina Niculescu, Radu Tamaian, Ioan Marcus, Iulia Luciana Popescu, Bogdan Sevastre), published in BOPI (The Official Industrial Property Bulletin of Romania), No. 3/2018, Section Patents, 30-03-2018, p. 65 (RO) © 2019, ICSI Rm. Vâlcea. Site created and updated by Nicolae Şofîlcă and Radu Tamaian |